GHRH & Peptides for Optimal Performance
Our hormone levels decline as we age, and therefore the effects of these hormones decline proportionally. Even if you exercise and eat well, you will still experience this decline in hormone production and all of the associated adverse health effects that this brings. To fight ageing, and increase vitality, we can restore our hormones to their youthful levels.
What is Peptide Therapy?
A peptide is a short chain of amino acids that are linked together, and can be thought of as a small protein. To date, over 7,000 naturally-occurring peptides have been identified. In our bodies, these small proteins typically act as signaling molecules. They bind to receptors on the cell surface and tell other cells and molecules what to do.
Peptide therapy, or the use of specific peptides in treatment, has gained great popularity in recent years. This is due largely to the fact that these peptides are highly specific (i.e., only do what you want them to do) while also being well-tolerated and safe. As of January 2015, there were over 60 US FDA-approved peptide medications, 140 peptide drugs being evaluated in clinical trials, and 500 in pre-clinical development.
Most of these peptide drugs are administered intradermally, but can also come in the form of transdermal creams, nasal sprays, and oral tablets.
What Conditions Does Peptide Therapy Address?
Because these peptides are so numerous and variable in structure, their effects are likewise varied and wide-ranging. One class of these peptides are known as growth hormone secretagogues, and cause the secretion of one’s own, natural hGH in the body. These peptides have been shown to be very useful in the treatment of age-related conditions, osteoporosis, obesity, and various chronic inflammatory diseases, and have several advantages over traditional hGH administration.
Another type of peptide drug is composed of part of the hGH molecule that is responsible for fat cell death, and has been shown to be very effective as an anti-obesity drug. In addition to decreasing inflammation, these drugs lead to increased lean muscle mass and decreased body fat.
Our GHRH & Peptides
This peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.
Sermorelin acetate is a biological active analog of growth hormone releasing factor (GRF 1-44) which is a growth hormone releasing hormone (GHRH) that is naturally produced by the human brain to stimulate production and secretion of human growth hormone (HGH) by the pituitary gland. Sermorelin is not a growth hormone; it is a growth hormone secretagogue, which means that it stimulates the pituitary gland by binding to specific receptors to increase the production and secretion of HGH. As a youth, ample amounts of growth hormone releasing hormone (GHRH) are produced so that the pituitary gland is able to provide the body with sufficient growth hormone to sustain health, vitality and otherwise normal aspects of human form and function. While aging, GHRH declines causing reduced production and secretion of pituitary HGH and thereby increasing growth hormone insufficiencies that erode health, stamina and vitality during later life.
Ipamorelin stands out among other GHSs due to its enhanced specificity. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated
Growth hormone releasing peptide (GHRP) 2 is a type of peptide therapeutic that mimics the effects of ghrelin, the “hunger hormone”. Ghrelin is a hormone that helps regulate appetite as well as energy distribution and rate of use, or metabolism. In the 1980’s, ghrelin was discovered to be the body’s natural ligand (or binding molecule) of the GHRP receptor in the anterior pituitary. This was a significant discovery, as it highlighted the role of ghrelin in hGH secretion and growth regulation. Modern biotechnology has used this knowledge to develop peptides that can be administered to mimic ghrelin’s hGH stimulation, but in a more targeted fashion. GHRP 2 is one such peptide, stimulating hGH secretion by 7-15 times, increasing appetite and meal initiation, while also decreasing fat mass and cholesterol. GHRP 2 is ideal for patients who are hypercatabolic, due to critical illness, cancer, AIDS, etc. It should be noted that GHRP 2 can also increase levels of prolactin, aldosterone, and cortisol.
Similar to GHRP 2, this peptide is a more potent releaser of growth hormone, also acting on the ghrelin receptors of the anterior pituitary. Also like GHRP 2, GHRP 6 leads to increased growth hormone production, increased lead body mass, and decreased adiposity. Due to the peptide’s ghrelin-like properties, administration can lead to increased appetite.
What is Ibutamoren Acetate? Ibutamoren is classified as a non-peptide growth hormone secretagogue and mimics the growth hormone stimulating action of ghrelin. Ibutamoren is considered to be potent, long-acting, and available through oral administration. Clinically, it has been demonstrated to increase endogenous release of growth hormone (GH) as well as insulin-like growth factor 1 (IGF-1) without the adverse increase of prolactin or cortisol often seen with GHRPs. Additionally, increases in lean body mass can be achieved while lowering LDL cholesterol. Studies have shown Ibutamoren stimulates brain regions involved with metabolic action, such as the hypothalamus and the pituitary. Ibutamoren may be effective in increasing both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty and osteoporosis in the elderly. Patient Benefits Over Time May Include:
• Increase muscle mass
• Decrease fat mass
• Faster Healing
• Firmer healthier skin
• Healthier hair
• Improved quality of sleep
• Combats aging
• Promotes longevity